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GLP-1 Drug Comparisons

By Rolando Valenzuela · Last reviewed June 25, 2026 · Editorial process

Side-by-side comparisons of every GLP-1 and next-generation obesity medication pair. Weight loss efficacy, mechanism, cost, and tolerability.

⚠️ Medical Disclaimer

This page is for educational purposes only and does not constitute medical advice. GLP-1 medications are prescription drugs. Discuss all treatment decisions with a licensed healthcare provider who knows your complete medical history. Individual results vary significantly from clinical trial averages.

Semaglutide vs Tirzepatide

14.9% vs 22.5% mean weight loss · STEP-1 vs SURMOUNT-1

Semaglutide vs Liraglutide

14.9% vs 8.0% mean weight loss · STEP-1 vs SCALE

Semaglutide vs Dulaglutide

14.9% vs 4.5% mean weight loss · STEP-1 vs AWARD-11

Semaglutide vs Retatrutide

14.9% vs 24.2% mean weight loss · STEP-1 vs TRIUMPH-3

Semaglutide vs Survodutide

14.9% vs 19.0% mean weight loss · STEP-1 vs SYNCHRONIZE-1

Semaglutide vs CagriSema

14.9% vs 22.7% mean weight loss · STEP-1 vs REDEFINE-1

Semaglutide vs Exenatide

14.9% vs 3.7% mean weight loss · STEP-1 vs DURATION-1

Tirzepatide vs Liraglutide

22.5% vs 8.0% mean weight loss · SURMOUNT-1 vs SCALE

Tirzepatide vs Dulaglutide

22.5% vs 4.5% mean weight loss · SURMOUNT-1 vs AWARD-11

Tirzepatide vs Retatrutide

22.5% vs 24.2% mean weight loss · SURMOUNT-1 vs TRIUMPH-3

Tirzepatide vs Survodutide

22.5% vs 19.0% mean weight loss · SURMOUNT-1 vs SYNCHRONIZE-1

Tirzepatide vs CagriSema

22.5% vs 22.7% mean weight loss · SURMOUNT-1 vs REDEFINE-1

Tirzepatide vs Exenatide

22.5% vs 3.7% mean weight loss · SURMOUNT-1 vs DURATION-1

Liraglutide vs Dulaglutide

8.0% vs 4.5% mean weight loss · SCALE vs AWARD-11

Liraglutide vs Retatrutide

8.0% vs 24.2% mean weight loss · SCALE vs TRIUMPH-3

Liraglutide vs Survodutide

8.0% vs 19.0% mean weight loss · SCALE vs SYNCHRONIZE-1

Liraglutide vs CagriSema

8.0% vs 22.7% mean weight loss · SCALE vs REDEFINE-1

Liraglutide vs Exenatide

8.0% vs 3.7% mean weight loss · SCALE vs DURATION-1

Dulaglutide vs Retatrutide

4.5% vs 24.2% mean weight loss · AWARD-11 vs TRIUMPH-3

Dulaglutide vs Survodutide

4.5% vs 19.0% mean weight loss · AWARD-11 vs SYNCHRONIZE-1

Dulaglutide vs CagriSema

4.5% vs 22.7% mean weight loss · AWARD-11 vs REDEFINE-1

Dulaglutide vs Exenatide

4.5% vs 3.7% mean weight loss · AWARD-11 vs DURATION-1

Retatrutide vs Survodutide

24.2% vs 19.0% mean weight loss · TRIUMPH-3 vs SYNCHRONIZE-1

Retatrutide vs CagriSema

24.2% vs 22.7% mean weight loss · TRIUMPH-3 vs REDEFINE-1

Retatrutide vs Exenatide

24.2% vs 3.7% mean weight loss · TRIUMPH-3 vs DURATION-1

Survodutide vs CagriSema

19.0% vs 22.7% mean weight loss · SYNCHRONIZE-1 vs REDEFINE-1

Survodutide vs Exenatide

19.0% vs 3.7% mean weight loss · SYNCHRONIZE-1 vs DURATION-1

CagriSema vs Exenatide

22.7% vs 3.7% mean weight loss · REDEFINE-1 vs DURATION-1