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Articles

Evidence-based guides.

Clinical-trial-grounded articles on GLP-1, peptide, and metabolic medications — what's prescribed today, what's coming next, and how to make sense of the science.

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Just Launched

Introducing the GLPTree Companion App: Track Your GLP-1 Journey in One Place

Track injections, weight, protein, and side effects — plus 100+ GLP-1 friendly recipes. Free to start. Premium optional.

4 min read Read more

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GLP-1 Access & Cost

Oral Wegovy Pill 2026: Complete US Launch Guide, Pricing & Dosing

Oral Wegovy launched in the US at $149/month and hit 3M+ prescriptions. Here's how the pill dosing schedule, pricing tiers, and efficacy compare to injectable Wegovy.

9 min read Read more

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GLP-1 Nutrition

30g Protein Greek Yogurt Parfait for GLP-1: The 5-Minute Breakfast That Actually Works

A 350-calorie, 30g protein breakfast parfait built for Ozempic, Wegovy, and Mounjaro appetites. Exact measurements, why it works, and how to nail your morning protein target.

6 min read Read more

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GLP-1 Safety

FDA Retatrutide Crackdown 2026: 16 Companies Warned, 6 in Liver Failure

The FDA warned 16 companies selling retatrutide online. 7 kept selling. Six Australians ended up in acute liver failure. Here's what the July 2026 crackdown means — and your safe legal options.

9 min read Read more

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GLP-1 Access & Cost

Compounded GLP-1 Legal Status 2026: What the FDA's Proposal Really Means

Is compounded semaglutide or tirzepatide still legal in 2026? Here's what the FDA's May proposal actually says, what's already changed, and your real options.

10 min read Read more

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GLP-1 Research & Safety

Stopping GLP-1s in 2026: What New Real-World Data Actually Shows

A new Cleveland Clinic study of nearly 8,000 patients found weight regain after stopping GLP-1s is far less severe than earlier trials suggested. Here's why.

10 min read Read more

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GLP-1 Research & Safety

GLP-1 Usage Hits Record 11% in 2026: Gallup's New Survey Explained

A new Gallup survey shows 11% of US adults now use GLP-1 drugs for weight loss, up from 3% in 2024, as obesity rates decline. Here's the full data breakdown.

8 min read Read more

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GLP-1 Research & Safety

Can You Lower Your GLP-1 Dose at Goal Weight? SURMOUNT-MAINTAIN 2026 Data

New Lancet trial data on tirzepatide dose reduction after reaching goal weight: what SURMOUNT-MAINTAIN found about lower maintenance doses vs. stopping.

9 min read Read more

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GLP-1 Cost & Coverage

Medicare GLP-1 Bridge 2026: The New $50 Copay Program Explained

Medicare's new GLP-1 Bridge program offers a $50 copay on Foundayo, Wegovy, and Zepbound starting July 2026. Here's who qualifies and how it works.

9 min read Read more

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Injection Guide

GLP-1 Injection Site Guide: Rotation, Bruising & What's Normal

A complete guide to GLP-1 injection sites: how to rotate weekly, prevent bruising, spot warning signs, and track everything in the GLPTree app.

10 min read Read more

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GLP-1 Side Effects

GLP-1 Hair Loss 2026: Why It Happens and the Regrowth Timeline That Actually Works

Hair shedding on Ozempic, Wegovy, or Mounjaro is real but usually temporary telogen effluvium. The mechanism, nutrient checklist, and regrowth timeline.

9 min read Read more

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GLP-1 Safety & News

GLP-1 Vision Risk 2026: What the New NAION Study Actually Found

A new JAMA Network Open study of 1.5 million patients found a 76% relative increase in a rare optic nerve condition tied to semaglutide and tirzepatide.

9 min read Read more

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GLP-1 Safety & News

GLP-1 Dosing Mistakes 2026: Why Poison Control Calls Nearly Doubled

A new Journal of Medical Toxicology study found GLP-1 poison control calls nearly doubled after FDA weight-loss approval. The two mistakes driving it.

9 min read Read more

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GLP-1 Safety & News

GLP-1 and Mental Health 2026: What the Latest Studies Say About Anxiety and Depression

New 2026 research shows semaglutide and tirzepatide have different, nuanced effects on anxiety and depression risk. What the real-world data shows.

10 min read Read more

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GLP-1 Education

GLP-1 and Intermittent Fasting 2026: When Combining Helps, When It Backfires

Should you do IF on Ozempic, Wegovy, or Mounjaro? Hypoglycemia risk, muscle loss, and an electrolyte protocol that protects results.

10 min read Read more

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GLP-1 Education

GLP-1 and Keto Diet 2026: Does Stacking Them Work or Is It Overkill?

Stacking keto with Ozempic, Wegovy, or Mounjaro? Keto-flu meets GLP-1 nausea, muscle preservation, and the keto-rebound risk when titrating off.

10 min read Read more

Editorial close-up of a single oval pill in a ceramic dish next to a glass of water — Foundayo oral GLP-1

GLP-1 Education

Foundayo (Orforglipron) 2026: The Complete Oral GLP-1 Pill Guide

Foundayo (orforglipron) FDA approved April 1, 2026 — the first oral GLP-1 pill with no food restrictions. Cost, efficacy, side effects, drug interactions.

11 min read Read more

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GLP-1 Education

GLP-1 and Birth Control Pills 2026: The Interaction Risk Every Woman Should Know

Mounjaro, Zepbound, and Foundayo all warn that oral birth control may fail. Safe contraceptive options and exactly how long backup is needed.

10 min read Read more

Strength-training flat lay: dumbbells, resistance band, protein powder, towel — preserving muscle on GLP-1

GLP-1 Education

GLP-1 Muscle Loss 2026: The Evidence-Based Guide to Keeping Your Strength

GLP-1 users move 11% less per ENDO 2026 data. Resistance training, protein, and ketone ester protocol that preserves 92% of muscle mass.

11 min read Read more

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Cost

Stopping GLP-1 Cold Turkey in 2026: What Two-Thirds Regain Looks Like

What clinical trials show happens when you stop GLP-1s — STEP 1 Extension, SURMOUNT-4, and the 2026 meta-analysis — plus a safer off-ramp.

9 min read Read more

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Retatrutide

Retatrutide Weight Loss Results: What Phase 2 Showed and What Phase 3 Will Tell Us

A complete look at the Phase 2 NEJM data (24.2% mean weight loss) and the May 2026 TRIUMPH-1 Phase 3 topline (28.3% at 80 weeks). What the responder rates and unreached plateau actually mean.

12 min read Read more

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Retatrutide

Triple Agonist Weight Loss Drugs Explained: How Retatrutide Combines GLP-1, GIP, and Glucagon

The mechanism behind the next generation of metabolic drugs. Why adding glucagon to GLP-1 and GIP increases energy expenditure, not just appetite suppression — and what it means for tolerability and safety.

11 min read Read more

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Retatrutide

Retatrutide FDA Approval Date: What's Known About the Timeline (2026 Update)

Lilly's confirmed Q4 2026 NDA filing intent, the TRIUMPH Phase 3 readout schedule, and three realistic FDA decision scenarios ranging from mid-2027 to early 2028.

10 min read Read more

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Retatrutide

Retatrutide Titration Schedule: How the Trial Doses Were Escalated

Side-by-side Phase 2 vs. TRIUMPH-1 Phase 3 dose-escalation schedules, the rationale for the added 6 mg step, and how retatrutide titration compares to tirzepatide and semaglutide.

10 min read Read more

Split molecular illustration: retatrutide versus tirzepatide on deep teal background

Comparison

Retatrutide vs Mounjaro: Head-to-Head Comparison of Trial Results

Why the right Mounjaro comparator is SURMOUNT-1 (obesity) and not SURPASS (T2D), and what the TRIUMPH-5 head-to-head trial will settle by late 2026.

11 min read Read more

Split molecular illustration comparing tirzepatide and retatrutide receptor agonism

Comparison

Tirzepatide vs Retatrutide: Which Produces More Weight Loss in the Trials?

A methodologically rigorous cross-trial comparison of SURMOUNT-1 (tirzepatide, 20.9%) and TRIUMPH-1 (retatrutide, 28.3%) — plus what each methodological difference can and can't explain.

11 min read Read more

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Nutrition

A Protein Strategy for Ozempic and Wegovy Users

How to meet protein targets when appetite is suppressed on Ozempic or Wegovy. Sample meal patterns, practical tips, and why protein protects muscle.

10 min read Read more

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Research Peptides

Peptide Therapy for Weight Loss: A Skeptical Guide to AOD-9604, Tesamorelin, and the 'Research Peptide' Market

An honest, evidence-based guide to peptides marketed for fat loss — AOD-9604, tesamorelin, BPC-157, and others — including what evidence exists, legal status, and consumer warnings.

11 min read Read more

Stylized molecular illustration on deep teal background — Ozempic vs Wegovy

Comparison

Ozempic vs. Wegovy: What's Actually Different?

Ozempic and Wegovy are the same molecule — semaglutide — but with key differences in approved dose, indication, insurance, and cost. Here's the full breakdown.

9 min read Read more

Stylized molecular illustration on deep teal background — next-gen GLP-1 medications

Next-Gen

The Next Generation of Weight Loss Medications: Retatrutide, Survodutide, and What's Coming After Tirzepatide

Plain-English guide to next-gen weight loss drugs in late-stage trials: retatrutide, survodutide, cagrisema — what they are, how they work, and what the data shows.

10 min read Read more

Stylized molecular illustration on deep teal background — Mounjaro vs Zepbound

Comparison

Mounjaro vs. Zepbound: Choosing Between Tirzepatide Brands

Mounjaro and Zepbound are the same drug — tirzepatide — in different packaging. Here's what determines which you get, and how costs differ.

9 min read Read more

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Side Effects

Managing GLP-1 Side Effects: Nausea, Fatigue, and 'Sulfur Burps

Evidence-based strategies for managing GLP-1 side effects including nausea, fatigue, constipation, and sulfur burps on Ozempic, Wegovy, or Mounjaro.

10 min read Read more

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Getting Started

How Much Weight Will You Lose on a GLP-1? Realistic Expectations from Clinical Trials

Plain-English breakdown of STEP, SURMOUNT, and SCALE trial data — what average weight loss on Wegovy, Mounjaro, and Ozempic looks like in the real world.

10 min read Read more

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Timeline

Plateaus on GLP-1 Medications: Why They Happen and What to Do

Why weight loss plateaus happen on Ozempic, Wegovy, and Mounjaro — the biology behind them, when to expect one, and evidence-based strategies to move forward.

9 min read Read more

Stylized molecular illustration on deep teal background — GLP-1 vs GLP-2

Biology

GLP-1 vs GLP-2: What's the Difference and Why It Matters

GLP-1 suppresses appetite and drives weight loss. GLP-2 is a gut growth hormone for short bowel syndrome. Learn why GLP-2 is not a weight loss therapy — and what's actually true.

9 min read Read more

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Dose

GLP-1 Dose Escalation: Why It Matters and What to Expect

A complete guide to GLP-1 dose escalation — why slow titration exists, what happens at each step on Wegovy, Ozempic, Zepbound, and when to ask about pausing.

9 min read Read more

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Cost

The Real Cost of GLP-1 Medications in 2026 (With and Without Insurance)

Full 2026 breakdown of GLP-1 medication costs with and without insurance — Ozempic, Wegovy, Mounjaro, Zepbound — plus savings cards, GoodRx, and compounding options.

10 min read Read more

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Getting Started

What to Expect in Your First 4 Weeks on a GLP-1 Medication

A week-by-week guide to your first month on Ozempic, Wegovy, or Mounjaro — appetite changes, side effects, and what's normal.

9 min read Read more

Plated protein foods on a warm-toned ceramic plate — eating on GLP-1

Nutrition

Eating on a GLP-1: Calorie Targets, Macros, and Why Less Isn't Always Better

How to set calorie and macro targets on Ozempic, Wegovy, or Mounjaro. Why extreme undereating backfires, muscle loss risks, and a practical nutrition framework.

10 min read Read more

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Cost

Compounded GLP-1s: What You Need to Know About Compounded Semaglutide and Tirzepatide

A complete guide to compounded semaglutide and tirzepatide — legal status in 2026, FDA stance, safety differences vs. branded drugs, cost comparison, and what to watch for.

11 min read Read more

Stylized molecular illustration on deep teal background — CagriSema and amylin

Next-Gen

CagriSema and the Amylin Story: Why Combination Therapies Are the Future of Weight Loss

CagriSema Phase 3 data explained — how combining semaglutide with the amylin analog cagrilintide produced 22.7% weight loss, and why amylin matters for obesity treatment.

10 min read Read more