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Evidence-based · Updated 2025 New — Retatrutide TRIUMPH trial tracker (28.7% weight loss readout) →

Tools for your
metabolic journey.

Evidence-based tools for the GLP-1, peptide, and metabolic medication landscape. Free calculators grounded in STEP, SURMOUNT, and SCALE — plus clinical-trial-backed guides on what's prescribed today and what's coming next, including investigational agents like retatrutide.

Project my weight loss Browse all calculators
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Based on clinical trial data from STEP, SURMOUNT, and SCALE trials.

STEP-1 · NEJM 2021 SURMOUNT-1 · NEJM 2022 SCALE · NEJM 2015

Calculators

Ten tools, all free.

Every calculator runs in your browser. We don't store your inputs.

Weight Loss Projector

See your expected loss curve based on trial data for your medication.

Calorie Target

Find your evidence-based calorie target with a GLP-1-aware deficit.

Protein Needs

Calculate daily protein and how to hit it across smaller GLP-1 meals.

Dose Schedule

Build your full escalation timeline with next-increase date.

Cost Estimator

Estimate monthly out-of-pocket cost by state, insurance, and savings card.

BMI Calculator

Calculate your BMI and see if you meet FDA criteria for GLP-1 medications.

TDEE Calculator

Find your calorie targets using Mifflin-St Jeor — framed for GLP-1 users.

Plateau Predictor

Predict when weight loss plateaus based on STEP-1 and SURMOUNT-1 trial data.

Goal Weight Timeline

Find out when you'll reach your goal weight with optimistic, median, and conservative estimates.

Medication Finder

A 7-question quiz to match your goals, insurance, and preferences to GLP-1 options.

Next-Generation

Retatrutide — the next-generation triple agonist

Retatrutide (Eli Lilly's LY3437943) is an investigational GLP-1 + GIP + glucagon triple receptor agonist currently in Phase 3 TRIUMPH trials. The TRIUMPH-4 readout in December 2025 showed 28.7% mean weight loss at 68 weeks — the highest reported in an obesity pharmacotherapy trial to date. Full peer-reviewed publication is pending FDA submission review.

Retatrutide is investigational. Not FDA-approved. Educational content only.

TRIUMPH Trial Tracker

Live status of TRIUMPH-1, 2, 3, 4, and Outcomes trials.

Phase 3 Status 2026

NCT IDs, completion dates, and enrollment status for all TRIUMPH trials.

Trial Dose Visualizer

Educational tool based on published protocol doses only.

Triple Agonist Mechanism

How GLP-1 + GIP + glucagon work together to produce outsized weight loss.

Retatrutide vs Orforglipron

Injectable triple agonist vs. oral GLP-1 — mechanism, efficacy, and pipeline comparison.

Cardiovascular Outcomes

TRIUMPH-3 and TRIUMPH-Outcomes cardiovascular data and endpoints.
Explore all Retatrutide content

Why GLPTree

Built for the long road.

Evidence-based

Projections use published efficacy from peer-reviewed trials, not anecdotes. We cite our sources on every page.

Free forever

No accounts, no paywalls, no email harvesting. Ads keep the lights on so the tools stay free.

Mobile-friendly

Designed for the phone in your pocket on injection day. Share your results with a link.

Brand Guides

Know your medication.

Complete guides for Ozempic, Wegovy, Mounjaro, Zepbound, and every major GLP-1 brand — dosing, side effects, costs, and comparisons.

All brand guides

Novo Nordisk

Ozempic

Semaglutide · T2D

Read guide →

Novo Nordisk

Wegovy

Semaglutide · Obesity

Read guide →

Eli Lilly

Mounjaro

Tirzepatide · T2D

Read guide →

Eli Lilly

Zepbound

Tirzepatide · Obesity

Read guide →
🔒 Also: Ozempic vs Wegovy  ·  Mounjaro vs Zepbound  ·  Wegovy vs Zepbound  ·  All 28 comparisons →

From the journal

Featured reading.

All articles
Wellness flat lay: notebook, glass of water, blueberries, and measuring tape on a warm cream surface
Getting Started

What to Expect in Your First 4 Weeks on a GLP-1 Medication

A week-by-week guide to your first month on Ozempic, Wegovy, or Mounjaro — appetite changes, side effects, and what's normal.

10 min read
Watercolor S-curve illustration of a figure walking along a winding weight-loss path
Getting Started

How Much Weight Will You Lose on a GLP-1? Realistic Expectations from Clinical Trials

Plain-English breakdown of STEP, SURMOUNT, and SCALE trial data — what average weight loss on Wegovy, Mounjaro, and Ozempic looks like in the real world.

10 min read
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Next-Gen

The Next Generation of Weight Loss Medications: Retatrutide, Survodutide, and What's Coming After Tirzepatide

Plain-English guide to next-gen weight loss drugs in late-stage trials: retatrutide, survodutide, cagrisema — what they are, how they work, and what the data shows.

11 min read